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April Edwards, MSc, PT, a licensed physiotherapist and Endomondo editorial team member, has reviewed this article. Her expertise ensures that our content provides reliable insights into our product recommendations.
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Healthy aging continues to gain attention as research reveals more about how we age and what affects our vitality, cognitive performance, and quality of life. This growing interest has fueled a booming supplement industry, now valued at over USD 152 billion.
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule that supports cellular functions, but its levels decline with age. Impaired NAD+ levels have been linked to aging, prompting interest in supplements that may help restore them, especially those targeting NAD+ for energy production.
In this article, we review some of the best NAD+ supplements available today. With longevity in mind, NAD+ supplementation may support energy metabolism, cellular repair, and cognitive function as we age.
What Is The Most Effective NAD+ supplement?
- PartiQlar Pure NR – Best Option With Third-Party Testing
- Wonderfeel Youngr NMN – Best Option With Added Ingredients
- Prohealth Longevity NAD+ Triple Boost™ 500mg – Best Overall
- Renue By Science LIPO NAD⁺ Complete – Best Combination Product
- THORNE NiaCel® 400 – Best Capsule Option
- CYMBIOTIKA NMN + Trans-Resveratrol – Best Option With Resveratrol
- Tru Niagen Pro® 1,000mg – Best Value
- Quicksilver Scientific NAD+ Platinum – Best Liquid Option
- Elysium Basis – Best Budget Option
Best NAD+ Supplements
Below is our expert-picked list of the best NAD+ supplements to try in 2025. Each product was chosen for its ingredient quality, brand transparency, and overall reputation. We’ve highlighted the key benefits and drawbacks of each to help you find the right fit for your energy, longevity, and cellular health goals.
PartiQlar Pure NR
- Each serving contains the research-proven 1000 milligram NR dose when two capsules are taken.
- Third-party tested with certificates of analysis provided.
- You can choose between one, three, and six bottles, allowing you to save money.
- Made in the US using Current Good Manufacturing Practice or cGMP-certified facilities.
- No added ingredients for additional benefits.
PartiQlar was founded by a team of health enthusiasts with years of experience in the health and wellness industry. The brand aims to provide effective, transparent, and trustworthy supplements. Because of this, each of them is validated by clinical trials. The PartiQlar Pure NR is the brand’s main NAD+ supplement offering.
The Pure NR focuses on ingredient quality, purity, and scientific transparency. Each vegan-friendly capsule contains 500 milligrams of 99% purity Nicotinamide Riboside or NR. This has been verified through high-quality third-party testing, with certificates of analysis to back it up.
This has been sourced from Effepharm, a reputable supplier that uses FDA-registered, cGMP-certified facilities. With this, you’re getting a clean formulation with no fillers, preservatives, and allergens.
PatiQlar offers the Pure NR in several tub sizes, giving you the option to purchase in bulk and save money. This includes a single bottle, three bottles, or a six-bottle pack. Purchasing the single bottle puts the price per serving at USD 1.83 when using a 1000 milligram daily dose.
Overall, PartiQlar’s Pure NR supplement offers excellent ingredient purity backed by high-quality scientific testing. Its clean formulation and commitment to transparency make it one of the best options if you’re looking for a clean NAD+ supplement. It’s our best option with third-party testing.
Wonderfeel Youngr NMN
- The 900 milligram NMN dose is the effective amount commonly used in research.
- Contains added trans-resveratrol, vitamin D, ergothioneine, and olive fruit extract.
- Third-party testing to ensure ingredient quality and effectiveness.
- The brand uses refillable glass bottles with recyclable pouch refills.
- The rice hull capsule component may break down in the stomach acid.
- There is only one serving size available.
Founded in 2018, Wonderfeel is a longevity-focused wellness brand. The brand’s creative team of doctors and entrepreneurs aims to create innovative wellness supplements using the body’s regenerative systems. The Wonderfeel Youngr NMN capsules are the brand’s flagship offering.
Among NMN supplements and NAD+ supplements, Wonderfeel Youngr capsules stand out for a few reasons. Each two-capsule serving contains 900 milligrams of NMN, the suggested effective amount commonly used in research. This gives you a potent NMN dose to enhance NAD levels and improve cellular function.
Furthermore, four added ingredients are included: trans-resveratrol, vitamin D, ergothioneine, and olive fruit extract. These further enhance NAD levels by optimizing cellular functions and reducing potential oxidative stress. This happens due to an imbalance of free radicals and antioxidants, causing cell damage. Because of this, they’re our best NAD+ supplement option with added ingredients.
In terms of overall quality, all the ingredients are manufactured in cGMP facilities in the US. Furthermore, they’re third-party tested, with trackable lab results provided for each batch. With this, you have a high-quality and well-formulated NAD+ supplement backed by science.
At USD 2.94 per serving, it’s quite expensive compared to other NAD+ options. However, you’re getting a multi-ingredient formulation with excellent testing and transparency. If you’ve got a larger budget, this is a fantastic option.
Prohealth Longevity’s products are triple-tested by a third-party lab, ensuring the highest quality. They are made in FDA-regulated facilities in the USA with good manufacturing practices, or GMP, certification. They also offer a 100-day risk-free guarantee of satisfaction with their product, or you’re entitled to a full refund!
Prohealth Longevity NAD+ Triple Boost™ 500mg
- Delivers 3 NAD+ precursors to optimize NAD+ generation pathways.
- 500mg of nicotinamide riboside, or NR, for enhanced NAD+ support.
- Provides a spectrum of B vitamins to support NAD+ cellular utilization.
- A combination formula may not be ideal for those who react poorly to one precursor.
- Not ideal for those who want to customize a specific precursor.
Prohealth Longevity NAD+ Triple Boost™ 500mg received our award for best overall choice. With its combination formula of NAD+ precursors and supporting ingredients, it’s easy to see why.
Prohealth Longevity has focused on health and longevity through supplements and education for 35 years. Its founder, Rich Carson, places a premium on providing the purest, highest-quality supplements to his customers. The Prohealth Longevity website is a trove of information about healthy aging, supplements, and nutrition.
NAD+ Triple Boost delivers a combination formula of three NAD+ precursors: nicotinamide riboside, niacin, and tryptophan. This targets three different pathways of NAD+ generation, optimizing levels within the body. Each one-capsule serving provides 500 milligrams of nicotinamide riboside, or NR, one of the most promising precursors in research.
Each serving also includes an array of B vitamins to support energy levels and NAD+ utilization in the cells. Apigenin, a compound derived from fruits and vegetables, helps protect NAD+ stores. BioPerine, synthesized from black pepper, boosts absorption and bioavailability.
Renue By Science LIPO NAD⁺ Complete
- Combination product containing four different NAD+ boosting compounds.
- Uses liposomal delivery to maximize absorption and utilization.
- Produced in an FDA-registered facility under GMP standards.
- Most expensive option.
Renue By Science LIPO NAD⁺ Complete was awarded the best combination product. Its exclusive formula combines four ingredients to deliver a powerful dose of NAD+-boosting potential.
Renue by Science was founded in 2017 by offering a series of NAD+ boosting products. Their product line has expanded, but continues to offer a variety of NAD+ supplements. They also succeeded in incorporating liposomal delivery to increase the absorption of the NAD+ precursors.
LIPO NAD+ Complete provides 160 mg NAD+ along with three different NAD+ precursors per serving. This includes 210 mg nicotinamide mononucleotide, or NMN, 170 mg trigonelline, and 100 mg NR. These are all delivered via liposomal powders included in each capsule.
Liposomes are tiny fluid-filled sacs that can bind together to form a barrier. This protects the active compounds from the gastrointestinal (GI) tract. In turn, this ensures they are more efficiently delivered to the bloodstream and synthesized by the body. Hence, it prevents the active compounds from losing potency in the GI tract or being excreted without being used.
LIPO NAD+ Complete is made from non-GMO ingredients. They are free from preservatives, artificial colors, flavors, and sweeteners. Each product is third-party tested and produced in a GMP-certified facility.
THORNE NiaCel® 400
- 415 mg per serving of an exclusive form of NR.
- Includes betaine for detox support and balanced brain chemicals.
- NSF Certified for Sport.
- Absorption rates may vary due to the exclusive NR form.
THORNE NiaCel® 400 received our award for the best capsule option. Their one-capsule serving is ideal for individuals who want a capsule option but may have trouble swallowing pills.
Thorne is a supplement company emphasizing a personalized approach to health and wellness. It offers a wide variety of supplements and testing to help its customers achieve their health goals. NiaCel 400 is one of four NAD+ boosting supplements they offer.
Each serving is just one capsule containing 415 mg of their exclusive form of NR. This can help boost your body’s NAD+ levels and support your health and wellness goals as you age.
Each serving also contains 85 mg of betaine, a naturally occurring chemical in your body. Betaine has been shown to improve body composition when taken supplementally. Therefore, NiaCel can support a healthy weight management program to help you achieve your health and wellness goals.
NiaCel is Certified for Sport through NSF International, ensuring there are no contaminants in the formulation. The capsules are gluten-free, dairy-free, soy-free, and vegan so they can complement a variety of diets.
CYMBIOTIKA NMN + Trans-Resveratrol
- 400 mg NMN per serving.
- Vegan-friendly, keto, and sugar-free.
- Includes resveratrol for added benefit.
- Contains caffeine, which may negatively affect sensitive individuals.
CYMBIOTIKA NMN + Trans-Resveratrol was awarded recognition as the best option with resveratrol. Each dose includes 100mg of resveratrol, more than other options on this list.
NMN + Trans-Resveratrol is just one of the many supplements offered by this San Diego, California-based health and wellness company. Cymbiotika has been producing a wide variety of dietary supplements since 2018. Unlike other companies on this list, this is their only NAD+ boosting supplement.
This supplement delivers 400 mg of NMN per two-capsule serving, in addition to several supporting ingredients. Apigenin, as discussed earlier, can preserve NAD+ stores within the body by preventing breakdown. Green tea extract may help reduce body weight and improve cholesterol levels.
The green coffee bean has several health benefits, as well as improving blood flow and absorption of active ingredients. Keep in mind that this ingredient will also add caffeine. This is important to note if you are particularly sensitive.
NMN + Trans-Resveratrol’s vegan-friendly capsules are made in the USA. They are compliant with a variety of diets, including keto. The website makes no mention of third-party testing or manufacturing practices.
Tru Niagen Pro® 1,000mg
- 1000 milligrams of NR per serving to maximize NAD+ support.
- Vegetarian, gluten-free, allergen-free, kosher, and halal certified.
- Third-party tested.
- No added support ingredients for additional benefits.
Tru Niagen Pro® 1,000mg was awarded our choice for the best value. This is because of its high dose of NAD+ precursor per serving compared to the price point.
Tru Niagen is the flagship product for ChromaDex, a leader in the international health and wellness market. Formulated with Niagen, a patented form of nicotinamide riboside, Tru Niagen was released worldwide in 2016. Since then, its popularity has continued to rise as ChromaDex is recognized for its high standards and safety in production.
Tru Niagen contains 1000 milligrams of NR, the highest dose per serving on this list. Because of this, it delivers the greatest value per serving of NAD+ precursor compared to other brands. While it may not contain any supporting ingredients, this is a clinical-strength serving of NR for optimal NAD+ support.
Niagen has ample evidence of its safety and efficacy from third-party-funded research. Additionally, the supplement Tru Niagen is third-party tested for safety, quality, and potency. It is produced in GMP-certified facilities with approval for use in sports by the National Sanitation Foundation, or NSF, International.
Quicksilver Scientific NAD+ Platinum
- Liquid formula.
- Gluten-free, allergen-free, soy-free, and sugar-free.
- Produced in a certified GMP facility.
- The smallest dose of NAD+ precursor on the list.
- Needs refrigeration.
Quicksilver Scientific NAD+ Platinum received our award for the best liquid option. It is the only liquid product on the list, ideal for those who want to avoid capsules.
Quicksilver Scientific NAD+ Platinum is the only liquid formulation on this list. This may appeal to those who do not like taking capsules. Their formula also utilizes a liposomal delivery system, improving absorption. The liposomal barrier prevents stomach acids from breaking down the active ingredients before they are absorbed into the bloodstream.
Each serving is half a teaspoon and delivers 50 mg of NMN, one of the most well-known NAD+ precursors. This is much lower than any other option on this list, something to keep in mind. The serving also contains supporting ingredients like vitamin B12, B2, trimethylglycine, quercetin, and resveratrol.
Resveratrol has been studied for its ability to activate sirtuin, which promotes health and lifespan extension. Dysregulation of this enzyme has been linked to neurological and heart disorders, and cancer. Sirtuin needs NAD+ to perform its functions, making resveratrol an important component in NAD+ boosting supplements.
This supplement is vegan-friendly and produced in a GMP-certified facility. The website discusses the purity of its products but does not mention third-party testing
Elysium Basis
- Contains 250 mg NR per serving.
- Includes pterostilbene, a protective polyphenol.
- NSF Certified for Sport.
- A combination formula may not be ideal for those sensitive to one ingredient.
Elysium Basis received our award for best budget option for its reasonable price point. This is a great choice if you want to try NAD+ supplements without breaking the bank.
Elysium was co-founded by an MIT researcher on the causes of aging. He translated his research into Basis, their main NAD+ supplement.
Basis is the only NAD+ supplement on this list to contain pterostilbene, a natural plant-based compound. This compound is known to protect the body from stress. It works with NR to boost NAD+ levels and promote sirtuin activity.
Each serving contains 250 mg of their patent-pending form of NR and 50 mg of pterostilbene for added benefit. These ingredients work together to combat cellular aging.
The capsules are vegan-friendly, gluten-free, and nut-free. They are NSF Certified for Sport, ensuring no contamination during production. This also means that the label shows exactly what you’re putting into your body when you take the supplement.
How Do NAD+ Supplements Work?
Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme found in every cell of the body. It plays a central role in energy production, DNA repair, and immune function. As we age, NAD+ levels naturally decline, contributing to fatigue, slower metabolism, and age-related health issues.
NAD+ supplements work by restoring these levels through NAD+ precursors, which are compounds the body uses to synthesize more NAD+. Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are two of the most studied and effective options. Once absorbed, the body converts these into usable NAD+.
To improve effectiveness, some products use liposomal delivery. This technique surrounds active ingredients in fat-based layers, helping them survive digestion and enter the bloodstream more efficiently.
Many formulas also include supportive compounds that enhance NAD+ activity or circulation. Ingredients like green coffee extract may promote vasodilation, allowing nutrients to travel more efficiently throughout the body.
Curious about NR vs. NMN supplements? There’s no definitive winner; both can increase NAD+ levels but may offer slightly different effects depending on the formula and your body’s response.
Benefits Of NAD+ Supplements
While protein powders and creatine are staples in fitness, NAD+ supplements are gaining recognition for their role in healthy aging. Though research is still evolving, the benefits of NAD+ supplements are drawing attention for their potential impact on metabolism, cognition, and vascular function.
Much of the current evidence stems from animal studies with promising outcomes. Human trials are limited, but early findings suggest NAD+ may support several areas of health, including NAD+ for cellular repair and mitochondrial function.
Improved Cardiovascular Health
As we age, the risk of cardiovascular disease rises, often due to arterial stiffness and elevated blood pressure. To mitigate this, researchers are exploring nutrients that may improve vascular health.
Among them, resveratrol supplements and NAD+ are frequently studied. Some studies suggest NAD+ may help lower systolic blood pressure and enhance arterial elasticity over time.
One clinical trial, for instance, found that six weeks of NR supplementation increased NAD+ levels in older adults. While the blood pressure changes weren’t statistically significant, the trend pointed toward improved cardiovascular support, highlighting a potential role for NAD+ in maintaining heart health as we age.
Decreased Systemic Inflammation
Chronic inflammation is a common factor in aging, even without noticeable symptoms. Over time, it can drive fatigue, metabolic imbalance, and elevate the risk of chronic illness.
In one study, just three weeks of NR supplementation reduced circulating inflammatory compounds. While more research is needed, these early results highlight NAD+ supplement benefits for immune health and age-related inflammation.
Improved Cognitive Abilities
Research into Alzheimer’s and neurodegenerative diseases is ongoing, with most current treatments focused on managing symptoms rather than prevention. As new therapeutic pathways emerge, NAD+ is being explored as a promising candidate for cognitive support.
A 2024 study found that NMN supplementation significantly increased NAD+ levels and showed signs of protecting neurological function. These findings suggest NAD+ for brain health may hold potential in slowing cognitive decline, though further long-term human studies are still needed.
Are NAD+ Supplements Safe?
The NAD+ precursors NR and NMN are generally considered safe and well-tolerated. However, studies have shown that some users may experience mild NAD+ supplement side effects, including muscle soreness, fatigue, headaches, or sleep disturbances, though these cases are uncommon.
Most available research focuses on short-term use, with limited data on long-term safety. This raises an important question: Are NAD+ supplements safe for ongoing use? More studies are needed to understand how long-term supplementation impacts the body.
It’s also important to assess the full ingredient list. Some formulas include added compounds like caffeine or herbal extracts that may cause sensitivity. Always read labels carefully and choose products from trusted brands.
If you have underlying health conditions or take medications, consult your healthcare provider before starting any NAD+ regimen. While early results are encouraging, long-term safety is still under review.
Conclusion
The best NAD+ supplements may support energy metabolism, cognitive performance, and cellular health as we age. By restoring declining NAD+ levels, they might aid the cardiovascular, muscular, and neurological systems, making NAD+ for longevity a growing area of interest.
That said, most evidence still comes from animal studies. While promising, human data remains limited, and more long-term research is needed to confirm these effects and ensure safety.
If you’re considering NAD+ supplements, consult a healthcare provider first. And when you’re ready to explore your options, this guide can help you choose a product that fits your needs and health goals.
Frequently Asked Questions
Individuals with health conditions such as liver or kidney disease, cancer, or autoimmune disorders should approach NAD+ supplements cautiously. Pregnant or breastfeeding women are also advised to avoid them. Young, healthy individuals may not benefit, and certain medications can interact with NAD+ pathways.
More research is needed, but current findings suggest general ranges. According to most NAD+ dosage guides, for NR, about 2,000 mg per day is typically considered safe with a low risk of side effects. For NMN, a daily dose of 500 mg is commonly cited as both safe and effective.
Animal research and early human trials show promise for NAD+ in healthy aging, energy, and cell function. But results in humans remain limited. While generally safe short term, long-term effects are unknown. Always consult a healthcare provider before taking any NAD+ supplement.
Like many supplements, mild side effects are possible, especially gastrointestinal ones like nausea, diarrhea, or cramping. Compared to fat burners, which often act quickly on metabolism, NAD+ supplements tend to work more subtly and gradually, with effects that aren’t fully understood yet.
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Endomondo.com refrains from utilizing tertiary references. We uphold stringent sourcing criteria and depend on peer-reviewed studies and academic research conducted by medical associations and institutions. For more detailed insights, you can explore further by reading our editorial process.
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About the Author
Tara Mitchell, DPT Doctor Of Physical Therapy
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