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Healthy aging continues to gain attention as research uncovers more about how we age and what influences our vitality, cognitive performance, and quality of life. This shift has fueled growth in the supplement industry, now valued at over USD 152 billion.
Nicotinamide adenine dinucleotide (NAD+) is a key molecule that supports many cellular functions, but its levels naturally decline as we get older. Impaired NAD+ levels have been linked to aging and related health challenges, leading to growing interest in how to restore them.
In this article, we review some of the best NAD+ supplements available today. With longevity in mind, NAD+ supplementation may offer support for energy metabolism, cellular repair, and cognitive health as we age.
What Is The Most Effective NAD+ supplement?
- Prohealth Longevity NAD+ Triple Boost™ 500mg – Best Overall
- THORNE NiaCel® 400 – Best Capsule Option
- CYMBIOTIKA NMN + Trans-Resveratrol – Best Option With Resveratrol
- Tru Niagen Pro® 1,000mg – Best Value
- Renue By Science LIPO NAD⁺ Complete – Best Combination Product
- Quicksilver Scientific NAD+ Platinum – Best Liquid Option
- Elysium Basis – Best Budget Option
Best NAD+ Supplements
Below, you’ll find our curated list of the best NAD+ supplements available in 2025. Each product was selected based on ingredient quality, transparency, and brand reputation. We’ve included the key pros and cons to help you decide which option best fits your health goals.
Prohealth Longevity NAD+ Triple Boost™ 500mg
- Delivers 3 NAD+ precursors to optimize NAD+ generation pathways.
- 500mg of nicotinamide riboside, or NR, for enhanced NAD+ support.
- Provides a spectrum of B vitamins to support NAD+ cellular utilization.
- A combination formula may not be ideal for those who react poorly to one precursor.
- Not ideal for those who want to customize a specific precursor.
Prohealth Longevity NAD+ Triple Boost™ 500mg received our award for best overall choice. With its combination formula of NAD+ precursors and supporting ingredients, it’s easy to see why.
Prohealth Longevity has focused on health and longevity through supplements and education for 35 years. Its founder, Rich Carson, places a premium on providing the purest, highest-quality supplements to his customers. The Prohealth Longevity website is a trove of information about healthy aging, supplements, and nutrition.
NAD+ Triple Boost delivers a combination formula of three NAD+ precursors: nicotinamide riboside, niacin, and tryptophan. This targets three different pathways of NAD+ generation, optimizing levels within the body. Each one-capsule serving provides 500 milligrams of nicotinamide riboside, or NR, one of the most promising precursors in research.
Each serving also includes an array of B vitamins to support energy levels and NAD+ utilization in the cells. Apigenin, a compound derived from fruits and vegetables, helps protect NAD+ stores. BioPerine, synthesized from black pepper, boosts absorption and bioavailability.
Prohealth Longevity’s products are triple-tested by a third-party lab, ensuring the highest quality. They are made in FDA-regulated facilities in the USA with good manufacturing practices, or GMP, certification. They also offer a 100-day risk-free guarantee of satisfaction with their product, or you’re entitled to a full refund!
THORNE NiaCel® 400
- 415 mg per serving of an exclusive form of NR.
- Includes betaine for detox support and balanced brain chemicals.
- NSF Certified for Sport.
- Absorption rates may vary due to the exclusive NR form.
THORNE NiaCel® 400 received our award for the best capsule option. Their one-capsule serving is ideal for individuals who want a capsule option but may have trouble swallowing pills.
Thorne is a supplement company emphasizing a personalized approach to health and wellness. It offers a wide variety of supplements and testing to help its customers achieve their health goals. NiaCel 400 is one of four NAD+ boosting supplements they offer.
Each serving is just one capsule containing 415 mg of their exclusive form of NR. This can help boost your body’s NAD+ levels and support your health and wellness goals as you age.
Each serving also contains 85 mg of betaine, a naturally occurring chemical in your body. Betaine has been shown to improve body composition when taken supplementally. Therefore, NiaCel can support a healthy weight management program to help you achieve your health and wellness goals.
NiaCel is Certified for Sport through NSF International, ensuring there are no contaminants in the formulation. The capsules are gluten-free, dairy-free, soy-free, and vegan so they can complement a variety of diets.
CYMBIOTIKA NMN + Trans-Resveratrol
- 400 mg NMN per serving.
- Vegan-friendly, keto, and sugar-free.
- Includes resveratrol for added benefit.
- Contains caffeine, which may negatively affect sensitive individuals.
CYMBIOTIKA NMN + Trans-Resveratrol was awarded recognition as the best option with resveratrol. Each dose includes 100mg of resveratrol, more than other options on this list.
NMN + Trans-Resveratrol is just one of the many supplements offered by this San Diego, California-based health and wellness company. Cymbiotika has been producing a wide variety of dietary supplements since 2018. Unlike other companies on this list, this is their only NAD+ boosting supplement.
This supplement delivers 400 mg of NMN per two-capsule serving, in addition to several supporting ingredients. Apigenin, as discussed earlier, can preserve NAD+ stores within the body by preventing breakdown. Green tea extract may help reduce body weight and improve cholesterol levels.
The green coffee bean has several health benefits, as well as improving blood flow and absorption of active ingredients. Keep in mind that this ingredient will also add caffeine. This is important to note if you are particularly sensitive.
NMN + Trans-Resveratrol’s vegan-friendly capsules are made in the USA. They are compliant with a variety of diets, including keto. The website makes no mention of third-party testing or manufacturing practices.
Tru Niagen Pro® 1,000mg
- 1000 milligrams of NR per serving to maximize NAD+ support.
- Vegetarian, gluten-free, allergen-free, kosher, and halal certified.
- Third-party tested.
- No added support ingredients for additional benefits.
Tru Niagen Pro® 1,000mg was awarded our choice for the best value. This is because of its high dose of NAD+ precursor per serving compared to the price point.
Tru Niagen is the flagship product for ChromaDex, a leader in the international health and wellness market. Formulated with Niagen, a patented form of nicotinamide riboside, Tru Niagen was released worldwide in 2016. Since then, its popularity has continued to rise as ChromaDex is recognized for its high standards and safety in production.
Tru Niagen contains 1000 milligrams of NR, the highest dose per serving on this list. Because of this, it delivers the greatest value per serving of NAD+ precursor compared to other brands. While it may not contain any supporting ingredients, this is a clinical-strength serving of NR for optimal NAD+ support.
Niagen has ample evidence of its safety and efficacy from third-party-funded research. Additionally, the supplement Tru Niagen is third-party tested for safety, quality, and potency. It is produced in GMP-certified facilities with approval for use in sports by the National Sanitation Foundation, or NSF, International.
Renue By Science LIPO NAD⁺ Complete
- Combination product containing four different NAD+ boosting compounds.
- Uses liposomal delivery to maximize absorption and utilization.
- Produced in an FDA-registered facility under GMP standards.
- Most expensive option.
Renue By Science LIPO NAD⁺ Complete was awarded the best combination product. Its exclusive formula combines four ingredients to deliver a powerful dose of NAD+-boosting potential.
Renue by Science was founded in 2017 by offering a series of NAD+ boosting products. Their product line has expanded but continues to offer a variety of NAD+ supplements. They also succeeded in incorporating liposomal delivery to increase the absorption of the NAD+ precursors.
LIPO NAD+ Complete provides 160 mg NAD+ along with three different NAD+ precursors per serving. This includes 210 mg nicotinamide mononucleotide, or NMN, 170 mg trigonelline, and 100 mg NR. These are all delivered via liposomal powders included in each capsule.
Liposomes are tiny fluid-filled sacs that can bind together to form a barrier. This protects the active compounds from the gastrointestinal (GI) tract. In turn, this ensures they are more efficiently delivered to the bloodstream and synthesized by the body. Hence, it prevents the active compounds from losing potency in the GI tract or being excreted without being used.
LIPO NAD+ Complete is made from non-GMO ingredients. They are free from preservatives, artificial colors, flavors, and sweeteners. Each product is third-party tested and produced in a GMP-certified facility.
Quicksilver Scientific NAD+ Platinum
- Liquid formula.
- Gluten-free, allergen-free, soy-free, and sugar-free.
- Produced in a certified GMP facility.
- The smallest dose of NAD+ precursor on the list.
- Needs refrigeration.
Quicksilver Scientific NAD+ Platinum received our award for the best liquid option. It is the only liquid product on the list, ideal for those who want to avoid capsules.
Quicksilver Scientific NAD+ Platinum is the only liquid formulation on this list. This may appeal to those who do not like taking capsules. Their formula also utilizes a liposomal delivery system, improving absorption. The liposomal barrier prevents stomach acids from breaking down the active ingredients before they are absorbed into the bloodstream.
Each serving is half a teaspoon and delivers 50 mg of NMN, one of the most well-known NAD+ precursors. This is much lower than any other option on this list — something to keep in mind. The serving also contains supporting ingredients like vitamin B12, B2, trimethylglycine, quercetin, and resveratrol.
Resveratrol has been studied for its ability to activate sirtuin, which promotes health and lifespan extension. Dysregulation of this enzyme has been linked to neurological and heart disorders, and cancer. Sirtuin needs NAD+ to perform its functions, making resveratrol an important component in NAD+ boosting supplements.
This supplement is vegan-friendly and produced in a GMP-certified facility. The website discusses the purity of its products but does not mention third-party testing
Elysium Basis
- Contains 250 mg NR per serving.
- Includes pterostilbene, a protective polyphenol.
- NSF Certified for Sport.
- A combination formula may not be ideal for those sensitive to one ingredient.
Elysium Basis received our award for best budget option for its reasonable price point. This is a great choice if you want to try NAD+ supplements without breaking the bank.
Elysium was co-founded by an MIT researcher on the causes of aging. He translated his research into Basis, their main NAD+ supplement.
Basis is the only NAD+ supplement on this list to contain pterostilbene, a natural plant-based compound. This compound is known to protect the body from stress. It works with NR to boost NAD+ levels and promote sirtuin activity.
Each serving contains 250 mg of their patent-pending form of NR and 50 mg of pterostilbene for added benefit. These ingredients work together to combat cellular aging.
The capsules are vegan-friendly, gluten-free, and nut-free. They are NSF Certified for Sport, ensuring no contamination during production. This also means that the label shows exactly what you’re putting into your body when you take the supplement.
How Do NAD+ Supplements Work?
Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme found in every cell of the body. It plays a key role in energy production, DNA repair, and immune function. As we age, NAD+ levels naturally decline, which has been linked to fatigue, slower metabolism, and age-related health concerns.
NAD+ supplements aim to restore these levels by supplying precursors—building blocks the body uses to produce more NAD+. Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are two of the most researched and widely used NAD+ precursors. After absorption, the body converts these compounds into usable NAD+.
Some supplements also use liposomal delivery to improve absorption. This method encapsulates the active ingredients in protective fat layers, helping them survive digestion and reach the bloodstream more effectively.
Formulas often include supporting ingredients that enhance the effect of NAD+ or improve circulation. For example, compounds like green coffee extract may promote vasodilation, helping nutrients travel more efficiently through the body.
Is one precursor better than the other? There’s no clear answer yet. Both NR and NMN help increase NAD+ levels, but they follow different metabolic pathways and may offer slightly different benefits depending on the formulation and your body’s response.
Benefits Of NAD+ Supplements
While some supplements like creatine or protein powder are well-established in the fitness world, NAD+ supplements are still emerging. Their potential benefits are gaining attention, but more human-based research is needed to confirm long-term effects.
Much of the existing data comes from animal studies, which have shown promising outcomes. Human trials remain limited, but early evidence suggests NAD+ may support several aspects of healthy aging.
Improved Cardiovascular Health
As we age, the risk of cardiovascular disease rises—often due to arterial stiffness and higher systolic blood pressure. To reduce this risk, researchers are exploring compounds that may support vascular health.
NAD+ is one of the compounds being researched for its potential cardiovascular benefits. Some studies suggest it may help lower blood pressure and improve arterial function over time.
For example, one clinical trial found that six weeks of NR supplementation raised NAD+ levels in middle-aged and older adults. While results on blood pressure improvement weren’t statistically significant, the trends were positive. These findings support the idea that NAD+ may play a role in protecting heart health as we age.
Decreased Systemic Inflammation
Chronic inflammation is a common feature of aging, even when symptoms aren’t obvious. Over time, it can contribute to metabolic imbalances, fatigue, and increased risk of chronic disease.
In one study, just three weeks of NR supplementation reduced circulating inflammatory compounds. While more research is needed to fully understand how NAD+ affects inflammation, these findings point to a potential role in supporting healthy immune and aging processes.
Improved Cognitive Abilities
Research into Alzheimer’s and other neurodegenerative disorders is ongoing, with most current treatments focused on symptom control rather than prevention. As science continues to explore new pathways, NAD+ has emerged as a promising candidate for supporting brain health.
A 2024 study showed that NMN supplementation helped boost NAD+ levels and may offer protective neurological benefits. These results suggest that NAD+ precursors could potentially slow the progression of Alzheimer’s and other age-related cognitive disorders, though more studies are needed to confirm long-term outcomes.
Are NAD+ Supplements Safe?
The NAD+ precursors NR and NMN are generally considered safe and well-tolerated. However, studies have shown that some individuals may experience mild side effects such as muscle soreness, fatigue, headaches, sleep issues, or nervous system discomfort—though these reports are relatively rare.
Most available research focuses on short-term use, and there’s limited data on long-term safety. As a result, more studies are needed to assess how NAD+ supplementation impacts the body with extended use.
It’s also important to evaluate the full ingredient list. Some formulations include added compounds like caffeine or herbal extracts that may cause sensitivity in certain users. Always check the label and choose supplements from reputable brands.
Before starting NAD+ supplements, talk to your healthcare provider—especially if you have underlying conditions or take medications. While early research is encouraging, safety over the long term is still being evaluated.
Conclusion
The best NAD+ supplements may offer support for energy metabolism, cognitive function, and overall cellular health—especially as we age. By helping replenish declining NAD+ levels, they could play a role in supporting cardiovascular, neurological, and muscular systems.
That said, while early research is promising, most findings come from animal studies. Human trials are still limited, and more long-term data is needed to fully understand their effects and safety.
If you’re thinking about adding NAD+ to your routine, speak with a healthcare professional first. And when you’re ready to explore your options, this guide to the best NAD+ supplements can help you choose a product that aligns with your needs and health goals.
Frequently Asked Questions
Individuals with specific health conditions, including liver or kidney issues, those with a history of cancer or inflammatory disorders, and pregnant or breastfeeding women, should exercise caution or avoid NAD supplements. Young, healthy people may not benefit from boosting NAD+ levels, and some medications may interact with NAD+ supplements.
More research is still needed to determine the best dose for NAD+ supplements. Based on current findings, the dosage depends on the precursor used. For NR, around 2,000 mg per day is generally considered safe with low risk of side effects. For NMN, a daily dose of 500 mg is often cited as both safe and effective.
While some animal studies and preliminary human trials show promise for NAD+ supplements in boosting health and slowing aging, more research is needed to confirm their effectiveness in humans. NAD+ supplements are generally considered safe in the short term, but long-term effects are unknown. Experts recommend consulting with a healthcare provider before taking any supplement, including NAD+.
Like many other supplements, there is a risk of mild side effects, particularly gastrointestinal issues such as nausea, diarrhea, and vomiting. Given NAD+’s role in essential cellular processes, there may also be downstream effects on metabolism that are not yet fully understood.
Resources
Endomondo.com refrains from utilizing tertiary references. We uphold stringent sourcing criteria and depend on peer-reviewed studies and academic research conducted by medical associations and institutions. For more detailed insights, you can explore further by reading our editorial process.
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Tara Mitchell, DPT Doctor Of Physical Therapy
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